What is Omeprazole? September 22 2015

Omeprazole (Prilosec, Zegerid) belongs to group of drugs called proton pump inhibitors. It decreases the amount of acid produced in the stomach.

Omeprazole is used to treat symptoms of gastroesophageal reflux disease (GERD) and other conditions caused by excess stomach acid. It is also used to promote healing of erosive esophagitis (damage to your esophagus caused by stomach acid).

Omeprazole may also be given together with antibiotics to treat gastric ulcer caused by infection with helicobacter pylori (H. pylori).


How should I take omeprazole?

Omeprazole is usually taken before eating (at least 1 hour before a meal). Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Prilosec OTC (over-the-counter) should be taken only once every 24 hours. Take the medicine in the morning before you eat breakfast. It may take up to 4 days for full effect.

Do not crush, chew, or break an enteric coated pill.

Use this medicine for the full prescribed length of time. Your symptoms may improve before your condition is completely cleared.


What other drugs will affect omeprazole?

Ask a doctor or pharmacist if it is safe for you to take omeprazole if you are also using any of the following drugs:

  • cilostazol;

  • clopidogrel;

  • diazepam (Valium);

  • digoxin;

  • disulfiram (Antabuse);

  • erlotinib;

  • iron-containing medicines (ferrous fumarate, ferrous gluconate, ferrous sulfate, and others);

  • methotrexate;

  • mycophenolate mofetil;

  • phenytoin;

  • St. John's wort;

  • tacrolimus;

  • warfarin (Coumadin, Jantoven);

  • an antibiotic--ampicillin, amoxicillin, clarithromycin, rifampin;

  • antifungal medicine--ketoconazole, voriconazole; or

  • HIV or AIDS medication--atazanavir, nelfinavir, saquinavir.

This list is not complete. Other drugs may interact with omeprazole, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.