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More than 50 million Americans suffer from frequent heartburn two or more days per week, the condition is not only painful, it can also impact their quality of life. Omeprazole is a proton-pump inhibitor and the world's top-selling drug for heartburn and gastroesophageal reflux disease (GERD). GERD is a condition in which backward flow of acid from the stomach causes heartburn and possible damage to the esophagus. Omeprazole works by decreasing the amount of acid produced in the stomach for up to 24 hours and is usually taken once a day on an empty stomach or at least 1 hour before eating a meal. It may be used with certain antibiotics to eliminate H. pylori and treat ulcers of the stomach and small intestines and to help prevent them from coming back. It may also be used to treat conditions that cause your body to make too much stomach acid (eg, Zollinger-Ellison syndrome). It may also be used for other conditions as determined by your doctor.